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COUNTERSTRIKE - Counteracting Sarcopenia with proteins and exercise - Screening the CALM cohort for lipoprotein biomarkers – University of Copenhagen


COUNTERacting Sarcopenia with proTeins and exeRcise - Screening the CALM cohort for lIpoprotein biomarKErs

A research project funded by Innovation Fund Denmark

Elderly lose up 2% of their skeletal muscle-mass per year, a condition termed sarcopenia”. In the coming years human longevity will increase in Western societies with huge socio-economic consequences. Thus, the ageing population should be encouraged to remain self-supportive, not only to diminish the economic burden for society, but also to retain their quality of life. University of Copenhagen is currently starting an ambitious intervention study “Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)” aimed at providing evidence-based recommendations for alleviating sarcopenia through protein supplementation and exercise. The project includes collection of a large number of blood and faecal samples to determine the impact of increased protein intake and exercise on the gut microbiota (GM) and the blood metabolome. COUNTERSTRIKE aims to complement the CALM project with a full metabolomic investigation of all its 3000 samples with emphasis on determination of lipoprotein particle distribution (LPD) and linking this to GM metabolomic potential and host physiological parameters. LPD predicts cardiovascular outcomes and is linked to obesity and insulin resistance. Body weight decreases with age, and a more atherogenic lipid profile is common, but little is known about LPD in elderly and how exercise and additional daily intake of protein affect their LPD. It is the ambition of this project that include national and international, academic and industrial power centres, to establish a rapid screening method for determination of LPD based on NMR spectroscopy, apply it to the CALM cohort and relate the results to GM and host metabolism and ultimatively making it available for future research in for eaxample personalized nutrition. The new screening method will allow for global screening of elderly to determine individual health status and facilitate a “COUNTERSTRIKE” against sarcopenia on the individual level creating a new business area for the European food industry.

Coordinator: Associate Professor Dennis Sandris Nielsen,  University of Copenhagen
Project period: 1 April 2015 – 31 March 2019
Funding: DKK 15,633,418 (Innovation Fund Denmark)
Additional funding from: Bruker BioSpin GmbH, Arla Foods Amba, Unilever R&D Vlaardingen, and all university partners